Catalytic asymmetric hydrogenation of methyl (E)-and (Z)-2-acetamido-3-alkylacrylates

JW Scott, DD Keith, G Nix Jr, DR Parrish…

文献索引：Scott, John W.; Keith, Dennis D.; Nix, George; Parrish, David R.; Remington, Stuart; et al. Journal of Organic Chemistry, 1981 , vol. 46, p. 5086 - 5093

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被引用次数: 58

摘要

Rhodium-chiral phosphine complex catalyzed homogeneous hydrogenations of methyl (2)- and (E)-a-acet-amido-4-methoxybut-2-enoates ((Z, E)-lO), methyl (2)-and (E)-2- acetamidohex-2-enoates ((Z, E)-lGA) and methyl (2)-and@')-2-acetamido-4-methylpent-2- enoates ((Z, E)-lGB) are reported. With phosphines in which two achiral phosphorus atoms are connected by a chiral four-carbon unit, higher product enantiomeric excesses (ee's) ...