Silicon-mediated synthesis of bibenzyl systems: synthesis of ring and side-chain functionalized hexestrol derivatives

R Mohan, JA Katzenellenbogen

文献索引：Mohan, Raju; Katzenellenbogen, John A. Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246

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被引用次数: 33

摘要

Derivatives of hexestrol [(3R*, 4S*)-3, 4-bis (4-hydroxyphenyl) hexane], a non-steroidal estrogen, bearing photochemically reactive functional groups or y-emitting radionuclides, are useful as affinity labeling agents for the estrogen receptor or as imaging agents for receptor positive breast tumors, respectively. We have developed convenient synthetic routes to two side chain functionalized and aromatic ring functionalized hexestrol ...