Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities

BJ Rodgers, NA Elsharif, N Vashisht…

文献索引：Rodgers, Brittney J.; Elsharif, Nada A.; Vashisht, Nisha; Mingus, MacY M.; Mulvahill, Mark A.; Stengel, Gudrun; Kuchta, Robert D.; Purse, Byron W. Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 2010 - 2015

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被引用次数: 8

摘要

Abstract Tricyclic cytosines (tC and tC O frameworks) have emerged as a unique class of fluorescent nucleobase analogues that minimally perturb the structure of B-form DNA and that are not quenched in duplex nucleic acids. Systematic derivatization of these frameworks is a likely approach to improve on and diversify photophysical properties, but has not so far been examined. Synthetic methods were refined to improve on tolerance for electron- ...