Tetrahedron

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Z Weng, H Li, W He, LF Yao, J Tan, J Chen, Y Yuan…

文献索引：Weng, Zhiqiang; Li, Huaifeng; He, Weiming; Yao, Liang-Feng; Tan, Jianwei; Chen, Jinfa; Yuan, Yaofeng; Huang, Kuo-Wei Tetrahedron, 2012 , vol. 68, # 11 p. 2527 - 2531

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被引用次数: 61

摘要

Trifluoromethylated acetylenes are a class of useful compounds due to their applications as building blocks for the synthesis of pharmaceuticals and the preparation of functional materials. 12 General methods for the preparation of trifluoromethylated acetylenes include the treatment of trifluoropropynyl metal reagents with aryl iodides, 13 dehalogenation of trifluoromethylethenes, 14 electrophilic trifluoromethylation of alkynyl lithium reagent 15 or trifluoromethylation of ...