Preparation of. alpha.-trifluoromethyl esters from malonic esters

…, ST Purrington, CL Bumgardner

文献索引：Everett, Stephen T.; Purrington, Suzanne T.; Bumgardner, Carl L. Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3702 - 3706

全文：HTML全文

被引用次数: 34

摘要

A wide variety of a-trifluoromethyl esters can be synthesized in two steps starting from monosubstituted malonic esters and dibromodifluoromethane. The product of the first step, a bromodifluoromethyl-substituted malonate, is transformed to the desired final product by use of KF in MezSO at elevated temperatures. This second step involves both the loss of one ester and halogen exchange and proceeds through an a,@-unsaturated ester in which ...