Parallel synthesis of isatin-based serine protease inhibitors

…, D Nasturica, C Gervais, MA Siddiqui, RF Rando…

文献索引：Shuttleworth, Stephen J.; Nasturica, Daniel; Gervais, Christian; Siddiqui, M. Arshad; Rando, Robert F.; Lee, Nola Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 22 p. 2501 - 2504

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被引用次数: 23

摘要

The synthesis of N-functionalised isatins using parallel, solution synthesis is described. Functionalised polymers were employed as stoichiometric and catalytic reagents as well as purification media in the exercise, and the derivatives were screened against a panel of serine proteases; high percentage inhibition was observed in several cases.