Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

RY Kuo, CC Wu, FR Chang, JL Yeh, J Chen…

文献索引：Kuo, Reen-Yen; Wu, Chin-Chung; Chang, Fang-Rong; Yeh, Jwu-Lai; Chen, Ing-Jun; Wu, Yang-Chang Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 821 - 823

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被引用次数: 20

摘要

Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d–9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.