Abstract An efficient synthesis of cis-2, 6-di-(2-quinolylpiperidine) has been developed. The key steps involve Wittig reaction of N-Cbz-protected cis-piperidine-2, 6-dicarboxaldehyde (3) with 2-(triphenylphosphinyl-methyl) quinoline bromide (4) and sequential removal of the N- Cbz group and double bond reduction. This synthetic procedure provides an efficient preparation for this useful norlobelane analogue.
