Cascade synthesis of (E)-2-alkylidenecyclobutanols

…, A Bandyopadhyay, N Puli, A Kundu, LM Reddy…

文献索引：Falck; He, Anyu; Manmohan Reddy; Kundu, Abhijit; Barma, Deb K.; Bandyopadhyay; Kamila, Sukanta; Akella, Radha; Bejot, Romain; Mioskowski, Charles Organic Letters, 2006 , vol. 8, # 20 p. 4645 - 4647

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被引用次数: 6

摘要

To better understand the implications of this unusual cascade reaction, we investigated its scope and possible mechanism and report our findings herein. The reaction parameters were systematically optimized using 1,1,1-trichloroalkane 5, α,β-unsaturated ketone 6, CrCl 2 (6 equiv), and CuCN (1.2 equiv) as the benchmark system. Yields of 7 were best in THF (Table 1, entry 1), somewhat lower in DME, CH 3 CN, and dioxane, and poor in DMF, HMPA, DMSO, and EtOAc. The ...