Some spiro analogs of the potent analgesic ketobemidone

…, DS Wilkinson, JR Thweatt, SP Halenda

文献索引：Rogers, M. E.; Wilkinson, D. S.; Thweatt, J. R.; Halenda, S. P. Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 688 - 690

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被引用次数: 6

摘要

Spiro derivatives of 4-phenylpiperidine analgesics would appear to be interesting receptor probes inasmuch as the rotation of the phenyl ring is restricted in such compounds. A number of examples have appeared in the literature and the importance of the torsional relationship between the aromatic group and the piperidine ring in nonspiro analgesics has received attention. ln-'Although biological data are not abundant, in general, spiro ...