A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl) methyl] guanine as a potent and selective anti-HBV agent

…, KY Roh, JT Hwang, S Ahn, HS Jang…

文献索引：Choi, Jong-Ryoo; Cho, Dong-Gyu; Roh, Kee Y.; Hwang, Jae-Taeg; Ahn, Sinbyoung; Jang, Hyun S.; Cho, Woo-Young; Kim, Kyong W.; Cho, Young-Gyo; Kim, Jeongmin; Kim, Yong-Zu Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2864 - 2869

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被引用次数: 59

摘要

9-[1-(Phosphonomethoxycyclopropyl) methyl] guanine (PMCG, 1), representative of a novel class of phosphonate nucleosides, blocks HBV replication with excellent potency (EC50= 0.5 μM) in a primary culture of HepG2 2.2. 15 cells. It exhibits no significant cytotoxicity in several human cell lines up to 1.0 mM. It does not inhibit replication of human immunodeficiency virus (HIV-1) or herpes simplex virus (HSV-1) at 30 μM. Many purine ...