A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl) methyl] guanine as a potent and selective anti-HBV agent

…, KY Roh, JT Hwang, S Ahn, HS Jang…

Index: Choi, Jong-Ryoo; Cho, Dong-Gyu; Roh, Kee Y.; Hwang, Jae-Taeg; Ahn, Sinbyoung; Jang, Hyun S.; Cho, Woo-Young; Kim, Kyong W.; Cho, Young-Gyo; Kim, Jeongmin; Kim, Yong-Zu Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2864 - 2869

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Citation Number: 59

Abstract

9-[1-(Phosphonomethoxycyclopropyl) methyl] guanine (PMCG, 1), representative of a novel class of phosphonate nucleosides, blocks HBV replication with excellent potency (EC50= 0.5 μM) in a primary culture of HepG2 2.2. 15 cells. It exhibits no significant cytotoxicity in several human cell lines up to 1.0 mM. It does not inhibit replication of human immunodeficiency virus (HIV-1) or herpes simplex virus (HSV-1) at 30 μM. Many purine ...