. alpha.-Fluorination of carbonyl compounds with trifluoromethyl hypofluorite

WJ Middleton, EM Bingham

文献索引：Middleton, W. J.; Bingham, E. M. Journal of the American Chemical Society, 1980 , vol. 102, # 14 p. 4845 - 4846

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被引用次数: 70

摘要

Sir: We have found a convenient, two-step method for the introduction of fluorine adjacent to the carbonyl group of ketones, aldehydes, esters, and amides. This is accomplished by first converting the carbonyl compounds to their trimethylsilyl enol ethers and then treating these resultant ethers with trifluoromethyl hypofluorite (CF30F) at-70 OC in an inert solvent to give directly the corresponding a-fluorocarbonyl compound. Previous investigators' have found ...