NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer: Part I. Discovering the guidelines

Y Cohen, E Bodner, M Richman, M Afri…

文献索引：Cohen, Yael; Bodner, Efrat; Richman, Michal; Afri, Michal; Frimer, Aryeh A. Chemistry and Physics of Lipids, 2008 , vol. 155, # 2 p. 98 - 113

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被引用次数: 19

摘要

The development of “molecular rulers” would allow one to quantitatively locate intercalants within the liposomal bilayer. To this end, we have attempted to correlate the 13C NMR chemical shift of a polarizable “reporter” carbon (eg, carbonyl) of the intercalant—with the ET (30) polarity it experiences, and with its Angstrom distance from the interface. This requires families of molecules with the same two “reporter carbons” separated by a fixed distance, ...