The Journal of Organic Chemistry

Temperature-dependent acid dissociation constants (Ka,. DELTA. Ha,. DELTA. Sa) for a series of nitrogen-substituted hydroxamic acids in aqueous solution

CP Brink, AL Crumbliss

文献索引：Poth Brink, Christina; Crumbliss, Alvin L. Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1171 - 1176

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被引用次数: 52

摘要

The acid dissociation constants (K,) of a series of eight substituted N- phenylacetohydroxamic acids, CH&-(O) N (OH) C&, X (X= H, 4-CH3, 4-C1, 4-1, 3-1, 3-CN, 4- CN, 4C (0) CH3), have been determined in aqueous solution (I= 2.0) for a range of temperatures. The pKa data at 25 OC exhibit a small variation with the substituent X in the direction expected according to their Hammett substituent constants (p= 0.1). These small ...