Synthesis of 3??aryl??4??isothiazolecarboxylates

RK Howe, TA Cruner, LG Carter…

文献索引：Howe,R.K. et al. Journal of Heterocyclic Chemistry, 1978 , vol. 15, p. 1001 - 1003

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被引用次数: 12

摘要

Abstract A short, convenient route to 3-aryl-4-isothiazolecarboxylates is described in which aryl Grig-nard reagents are added to the magnesium etiolate of ethyl cyanoacetete, and the resultant β-aminocinnamates are converted via a Vilsmeier-Haack reaction, thiation, and oxidation to the isothiazolecarboxylates.