Bioorganic & medicinal chemistry letters

Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl) ethyl] pyrrolidine-2, 5-diones

K Kamiński, S Rzepka, J Obniska

文献索引：Kaminski, Krzysztof; Rzepka, Sabina; Obniska, Jolanta Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5800 - 5803

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被引用次数: 30

摘要

Twenty-two new 1-[2-oxo-2-(4-phenylpiperazin-1-yl) ethyl] pyrrolidine-2, 5-diones were synthesized and tested for anticonvulsant activity. Initial anticonvulsant screening was performed using standard maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens in mice. Several compounds were tested additionally in the 6-Hz psychomotor seizure model. The neurotoxicity was determined applying the ...