Tetrahedron Letters

Efficient synthesis of the siderophore petrobactin via antimony triethoxide mediated coupling

RK Pandey, GG Jarvis, PS Low

文献索引：Pandey, Rajesh K.; Jarvis, Gregory G.; Low, Philip S. Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1627 - 1629

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被引用次数: 3

摘要

Because of the high affinities and specificities of siderophores for their cognate pathogens, 10 siderophore–antibiotic conjugates have been recently exploited as a tool for the selective killing of the source pathogen. 11, 12 and 13 Bacillus species, including B. anthracis and B. cereus, recognize the 3,4-catecholate siderophore called petrobactin ( Fig. 1). 14 Petrobactin–iron chelate complexes in turn bind cell surface receptor-like proteins, FpuA, ...