Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

…, C Mellon, N Méthot, M Ndao, D Nicoll-Griffith…

文献索引：Beaulieu, Christian; Isabel, Elise; Fortier, Angelique; Masse, Frederic; Mellon, Christophe; Methot, Nathalie; Ndao, Momar; Nicoll-Griffith, Deborah; Lee, Doris; Park, Hyeram; Black, W. Cameron Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7444 - 7449

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被引用次数: 25

摘要

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P2 portion led to the identification of compounds, such as 26, that have a unique selectivity profile against other cysteine proteases and offering new opportunities for safer treatment of Chagas disease.