Abstract The first total synthesis of tunicamycin V, a major component of tunicamycin homologus, is described. Condensation of 2-acetamido-2-deoxy-4, 6-O-isopropylidene-3-O- propanoyl-α-d-glucopyranose with 1-[(11R)-2, 3, 5, 8, 9-penta-O-acetyl-10-( ...