A Simple and Versatile Route to Novel Conjugated β-Enaminonitriles and Their Application for the Highly Regioselective Synthesis of Nicotinonitriles Using a …

AR Katritzky, A Denisenko, M Arend

文献索引：Katritzky, Alan R.; Denisenko, Anna; Arend, Michael Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6076 - 6079

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被引用次数: 25

摘要

A straightforward synthesis of conjugated β-enaminonitriles from ketones and β- aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel dienamines with a Vilsmeier-type reagent provides a mild and highly regioselective route for the preparation of nicotinonitriles.