The lactam ring system is one of the most ubiquitous structural motifs found in natural products and pharmaceuticals. 1 Owing to the prevalence of lactams, their synthesis has attracted considerable attention. Lactams are usually prepared by the coupling of activated carboxylic acid derivatives with amines. 2 Alternative routes include the Beckmann rearrangement of oximes, 3 the Schmidt reaction of cyclic ketones and hydrazoic acid, 4 ...
