Direct Lactamization of Azido Amides via Staudinger-Type Reductive Cyclization

IJ Heo, SJ Lee, CW Cho

Index: Heo, In-Jung; Lee, Su-Jeong; Cho, Chang-Woo Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 1 p. 333 - 336

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Abstract

The lactam ring system is one of the most ubiquitous structural motifs found in natural products and pharmaceuticals. 1 Owing to the prevalence of lactams, their synthesis has attracted considerable attention. Lactams are usually prepared by the coupling of activated carboxylic acid derivatives with amines. 2 Alternative routes include the Beckmann rearrangement of oximes, 3 the Schmidt reaction of cyclic ketones and hydrazoic acid, 4 ...