Substituted benzo [i] phenanthridines as mammalian topoisomerase-targeting agents

…, B Zhao, SP Sim, TK Li, A Liu, LF Liu, EJ LaVoie

文献索引：Makhey, Darshan; Li, Dajie; Zhao, Baoping; Sim, Sai-Peng; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1809 - 1820

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被引用次数: 40

摘要

Several benzo [c] phenanthridine and protoberberine alkaloids, such as nitidine and berberrubine, are known to induce DNA cleavage in the presence of either topoisomerase I or II. Structure–activity studies performed on various analogues related to benzo [c] phenanthridine and protoberberine alkaloids have provided insights into structural features that influence this topoisomerase-targeting activity. Modifications within the A-ring of ...