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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Isocytosine H2-receptor histamine antagonists I. Oxmetidine and related compounds

…, CR Ganellin, ME Parsons, DA Rawlings…

文献索引：Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62

全文：HTML全文

被引用次数: 45

摘要

Abstract A series of 2-[2-(5-methyl-4-imidazolylmethylthio) ethylamino]-4-pyrimidones was prepared based on cimetidine 1. The model compound 4 has modest H 2-antagonist activity as shown by its ability to antagonise histamine-stimulated tachycardia in guinea pig right atrium in vitro and inhibit histamine-stimulated gastric acid secretion in the lumen-perfused stomach of the anaesthetised rat. Investigation of the effect of substituents in the ...

(E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate结构式

(E)-ethyl 3-(3-...

~%

间三氟甲基苯丙酸乙酯结构式

间三氟甲基苯丙酸乙酯

间三氟甲基苯甲醛结构式

间三氟甲基苯甲醛

~%

间三氟甲基苯丙酸乙酯结构式

间三氟甲基苯丙酸乙酯

胡椒醛结构式

乙醇结构式

丙二酸结构式

~%

ethyl (E)-3-(1,3-benzodioxol-5-yl)acrylate结构式

ethyl (E)-3-(1,...

胡椒醛结构式

~%

1,3-Benzodioxole-5-propanoic acid, ethyl ester结构式

1,3-Benzodioxol...

3,4,5-三甲氧基肉桂酸乙酯结构式

3,4,5-三甲氧基肉桂酸乙酯

~%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

3,4,5-三甲氧基苯甲醛结构式

3,4,5-三甲氧基苯甲醛

~%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

5-(3,4,5-trimethoxybenzyl)-2-methylthio-4-pyrimidone结构式

5-(3,4,5-trimet...

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~39%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

3-(3,4,5-三甲氧基苯基)丙酸乙酯结构式

3-(3,4,5-三甲氧基苯基)丙酸乙酯

~%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

5-(3,4,5-trimethoxybenzyl)-2-thiouracil结构式

5-(3,4,5-trimet...

~%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

4(1H)-Pyrimidinone, 2-(methylthio)-5-(phenylmethyl)-结构式

4(1H)-Pyrimidin...

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~62%

5-benzyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-benzyl-2-[2-[...

5-苄基-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮结构式

5-苄基-2-硫氧代-2,3-...

~%

5-benzyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-benzyl-2-[2-[...

ethyl 2-formyl-3-phenylpropionate结构式

ethyl 2-formyl-...

~%

5-benzyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-benzyl-2-[2-[...

邻甲氧基苯甲醛结构式

邻甲氧基苯甲醛

~%

3-(2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER结构式

3-(2-METHOXY-PH...

对氯肉桂酸乙酯结构式

对氯肉桂酸乙酯

~%

5-(4-氯苄基)-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮结构式

5-(4-氯苄基)-2-硫氧代...

对氯苯甲醛结构式

对氯苯甲醛

~%

5-(4-氯苄基)-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮结构式

5-(4-氯苄基)-2-硫氧代...

4-氯苯丙酸乙酯结构式

4-氯苯丙酸乙酯

~%

5-(4-氯苄基)-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮结构式

5-(4-氯苄基)-2-硫氧代...

trans-1-ethoxycarbonyl-2-(3-methoxyphenyl)ethylene结构式

trans-1-ethoxyc...

~%

4(1H)-Pyrimidinone,2,3-dihydro-5-[(3-methoxyphenyl)methyl]-2-thioxo-结构式

4(1H)-Pyrimidin...

3-甲氧基苯甲醛结构式

3-甲氧基苯甲醛

~%

4(1H)-Pyrimidinone,2,3-dihydro-5-[(3-methoxyphenyl)methyl]-2-thioxo-结构式

4(1H)-Pyrimidin...

4-甲氧基苯甲醛; 对甲氧基苯甲醛; 大茴香醛结构式

4-甲氧基苯甲醛; 对甲氧基苯...

~%

3-(4-甲氧基苯基)丙酸乙酯结构式

3-(4-甲氧基苯基)丙酸乙酯

未登录结构式

~%

5-[(4-fluorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(4-fluorophe...

对氟苯甲醛结构式

对氟苯甲醛

~%

5-[(4-fluorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(4-fluorophe...

3-(4-氟苯基)丙酸乙酯结构式

3-(4-氟苯基)丙酸乙酯

~%

5-[(4-fluorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(4-fluorophe...

5-(4-fluorobenzyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one结构式

5-(4-fluorobenz...

~%

5-[(4-fluorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(4-fluorophe...

胡椒醛结构式

~%

5-(1,3-benzodioxol-5-ylmethyl)-2-(nitroamino)-1H-pyrimidin-4-one结构式

5-(1,3-benzodio...

ethyl (E)-3-(1,3-benzodioxol-5-yl)acrylate结构式

ethyl (E)-3-(1,...

~%

5-(1,3-benzodioxol-5-ylmethyl)-2-(nitroamino)-1H-pyrimidin-4-one结构式

5-(1,3-benzodio...

1,3-Benzodioxole-5-propanoic acid, ethyl ester结构式

1,3-Benzodioxol...

~%

5-(1,3-benzodioxol-5-ylmethyl)-2-(nitroamino)-1H-pyrimidin-4-one结构式

5-(1,3-benzodio...

丁酰乙酸乙酯结构式

丁酰乙酸乙酯

thiourea结构式

~%

丙硫氧嘧啶结构式

丙硫氧嘧啶

对氯苯甲醛结构式

对氯苯甲醛

~%

4-氯苯丙酸乙酯结构式

4-氯苯丙酸乙酯

2-Propenoic acid, 3-(3-chlorophenyl)-, ethyl ester结构式

2-Propenoic aci...

~%

5-[(3-chlorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(3-chlorophe...

3-氯苯甲醛结构式

~%

5-[(3-chlorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(3-chlorophe...

未登录结构式

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~57%

5-[(3-chlorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(3-chlorophe...

未登录结构式

~%

5-[(3-chlorophenyl)methyl]-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

5-[(3-chlorophe...

胡椒醛结构式

~%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

ethyl (E)-3-(1,3-benzodioxol-5-yl)acrylate结构式

ethyl (E)-3-(1,...

~%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

1,3-Benzodioxole-5-propanoic acid, ethyl ester结构式

1,3-Benzodioxol...

~%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

2-methylthio-5-(3,4-methylenedioxybenzyl)pyrimid-4-one结构式

2-methylthio-5-...

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~47%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

未登录结构式

~%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

5-(1,3-benzodioxol-5-ylmethyl)-2-(nitroamino)-1H-pyrimidin-4-one结构式

5-(1,3-benzodio...

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~%

5-(1,3-苯并二氧-5-甲基)-2-[[2-[[(5-甲基-1h-咪唑-4-基)甲基]硫代]乙基]氨基]-1h-嘧啶-4-酮二盐酸盐结构式

5-(1,3-苯并二氧-5-甲...

3-(3-ethoxy-phenyl)-acrylic acid ethyl ester结构式

3-(3-ethoxy-phe...

~%

4(1H)-Pyrimidinone,5-[(3-ethoxyphenyl)methyl]-2,3-dihydro-2-thioxo-结构式

4(1H)-Pyrimidin...

未登录结构式

~%

4(1H)-Pyrimidinone,5-[(3-ethoxyphenyl)methyl]-2,3-dihydro-2-thioxo-结构式

4(1H)-Pyrimidin...

未登录结构式

~%

5-[(4-methylphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one结构式

5-[(4-methylphe...

对甲基苯甲醛结构式

对甲基苯甲醛

~%

5-[(4-methylphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one结构式

5-[(4-methylphe...

4-甲基苯丙酸乙酯结构式

4-甲基苯丙酸乙酯

~%

5-[(4-methylphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one结构式

5-[(4-methylphe...

藜芦醛； 3,4-二甲氧基苯甲醛结构式

藜芦醛； 3,4-二甲氧基苯甲醛

~%

ethyl 3-(3,4-dimethoxyphenyl)propanoate结构式

ethyl 3-(3,4-di...

2-甲硫基-4-嘧啶酮结构式

2-甲硫基-4-嘧啶酮

2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺结构式

2-(((5-甲基-1H-咪唑...

~64%

2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethylamino]-1H-pyrimidin-6-one,dihydrochloride结构式

2-[2-[(5-methyl...

未登录结构式

~%

4-甲基苯丙酸乙酯结构式

4-甲基苯丙酸乙酯

对甲基苯甲醛结构式

对甲基苯甲醛

~%

4-甲基苯丙酸乙酯结构式

4-甲基苯丙酸乙酯

3-arylpropanoate esters through the palladium-catalyzed reac...

[Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta Synlett, 2003 , # 8 p. 1133 - 1136]

Inhibition of uridine phosphorylase: synthesis and structure...

[Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856]