Tetrahedron

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

…, T Boisse, JP Hénichart, A Daïch, B Rigo, P Gautret

文献索引：Gavara, Laurent; Boisse, Thomas; Henichart, Jean-Pierre; Daich, Adam; Rigo, Benoit; Gautret, Philippe Tetrahedron, 2010 , vol. 66, # 38 p. 7544 - 7561

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被引用次数: 5

摘要

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.