A novel and practical synthesis of 2-amino-5-hydroxypropiophenone

XD Xiong, WX Chen, YY Kuang…

文献索引：Xiong, Xiao-Dong; Chen, Wen-Xue; Kuang, Yun-Yan; Chen, Fen-Er Organic Preparations and Procedures International, 2009 , vol. 41, # 5 p. 423 - 427

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被引用次数: 6

摘要

In connection with our recent development of an efficient asymmetric total synthesis of irinotecan (CPT-11, 1), an analogue of the natural product camptothecin, approved by the FDA for treatment of refractory colorectal cancer, 1, 2 2-amino-5-hydroxypropiophenone (2) was required as a key intermediate for the construction of the AB ring with (4 S)-tricyclic hydroxylactone 3, another known intermediate bearing CDE ring skeleton for the ...