Chemistry–A European Journal

Protease catalysis mediated by a substrate mimetic: a novel enzymatic approach to the synthesis of carboxylic acid amides

R Günther, F Bordusa

文献索引：Guenther, Robert; Bordusa, Frank Chemistry - A European Journal, 2000 , vol. 6, # 3 p. 463 - 467

全文：HTML全文

被引用次数: 24

摘要

Abstract A general method of overcoming the original specificity of proteases is illustrated by a combination of the substrate mimetic strategy shown here with the broad S′-subsite specificity of the protease clostripain. Besides the synthesis of peptide isosteres and analogues, the biocatalytic approach presented allows the coupling of completely non- amino-acid-derived carboxy and amino components.