Organic process research & development

N-Acylation Reactions Performed in Aqueous Reaction Medium: Screening and Optimising of a Synthetic Step of a Process for Iodixanol

HR Bjørsvik, T Engell

文献索引：Bjorsvik, Hans-Rene; Engell, Torgrim Organic Process Research and Development, 2002 , vol. 6, # 2 p. 113 - 119

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被引用次数: 2

摘要

This contribution presents results from a development and optimisation project concerning a synthetic process for iodixanol. Iodixanol is the “active ingredient” in Visipaque (Nycomed Amersham now Amersham Health) a medical X-ray imaging contrast agent. The process step that was developed and optimised comprised a reaction between a tetraacid chloride and 3-aminopropane-1, 2-diol for obtaining the corresponding tetraamide. This reaction ...