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Tetrahedron

New 5-(2-ethenylsubstituted)-3 (2H)-furanones with in vitro antiproliferative activity

S Chimichi, M Boccalini, B Cosimelli, F Dall'Acqua…

文献索引:Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Dall'Acqua, Francesco; Viola, Giampietro Tetrahedron, 2003 , vol. 59, # 28 p. 5215 - 5223

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被引用次数: 36

摘要

A convenient route to new 3 (2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived ...