e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

New 5-(2-ethenylsubstituted)-3 (2H)-furanones with in vitro antiproliferative activity

S Chimichi, M Boccalini, B Cosimelli, F Dall'Acqua…

Index: Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Dall'Acqua, Francesco; Viola, Giampietro Tetrahedron, 2003 , vol. 59, # 28 p. 5215 - 5223

Full Text: HTML

Citation Number: 36

Abstract

A convenient route to new 3 (2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived ...

2-(3-Ethylisoxazol-5-yl)propan-2-ol Structure

2-(3-Ethylisoxa...

~72%

5-ethyl-2,2-dimethylfuran-3-one Structure

5-ethyl-2,2-dim...

3-Methyl butynol Structure

3-Methyl butynol

~%

5-ethyl-2,2-dimethylfuran-3-one Structure

5-ethyl-2,2-dim...

3-Methyl butynol Structure

3-Methyl butynol

~%

2,2-dimethyl-5-prop-1-en-2-yl-furan-3-one Structure

2,2-dimethyl-5-...

2-(3-Ethylisoxazol-5-yl)propan-2-ol Structure

2-(3-Ethylisoxa...

~%

2,2-dimethyl-5-prop-1-en-2-yl-furan-3-one Structure

2,2-dimethyl-5-...

5-ethyl-2,2-dimethylfuran-3-one Structure

5-ethyl-2,2-dim...

~%

2,2-dimethyl-5-prop-1-en-2-yl-furan-3-one Structure

2,2-dimethyl-5-...

Ethanone, 1-(3-ethyl-4,5-dihydro-5-isoxazolyl)- (9CI) Structure

Ethanone, 1-(3-...

~76%

Ethanone, 1-(3-ethyl-5-isoxazolyl)- (9CI) Structure

Ethanone, 1-(3-...

1-(3-Methylisoxazol-5-yl)ethanol Structure

1-(3-Methylisox...

~79%

2,5-Dimethyl-3(2H)-Furanone Structure

2,5-Dimethyl-3(...

1-(3-Methylisoxazol-5-yl)ethanone Structure

1-(3-Methylisox...

~%

1-(3-Methylisoxazol-5-yl)ethanol Structure

1-(3-Methylisox...

(E)-acetaldoxime Structure

(E)-acetaldoxime

3-Butyn-2-ol Structure

~%

1-(3-Methylisoxazol-5-yl)ethanol Structure

1-(3-Methylisox...

Nitroethane Structure

3-Butyn-2-ol Structure

~%

1-(3-Methylisoxazol-5-yl)ethanol Structure

1-(3-Methylisox...

Ethyl 5-substituted-3-isoxazolecarboxylates as starting mate...

[Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4313 - 4316]

Reduction of Δ 2-isoxazolines-2. A facile synthesis of 3 (2H...

[Curran, Dennis P.; Singleton, David H. Tetrahedron Letters, 1983 , vol. 24, # 20 p. 2079 - 2082]

Ethyl 5-substituted-3-isoxazolecarboxylates as starting mate...

[Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4313 - 4316]

Reduction of Δ 2-isoxazolines-2. A facile synthesis of 3 (2H...

[Curran, Dennis P.; Singleton, David H. Tetrahedron Letters, 1983 , vol. 24, # 20 p. 2079 - 2082]

Ethyl 5-substituted-3-isoxazolecarboxylates as starting mate...

[Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4313 - 4316]