Tetrahedron letters

Mannich reactions of π-excessive heterocycles using bis-(dialkylamino) methanes and alkoxydialkylaminomethanes activated with acetyl chloride or sulphur dioxide

SC Eyley, H Heaney, G Papageorgiou, RF Wilkins

文献索引：Eyley, Stephen C.; Heaney, Harry; Papageorgiou, George; Wilkins, Robert F. Tetrahedron Letters, 1988 , vol. 29, # 24 p. 2997 - 3000

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被引用次数: 23

摘要

Abstract Π-Excessive heterocycles react rapidly with bis (dialkylamino) methanes (aminals) and alkoxydialkylaminomethanes (aminol ethers) in acetonitrile to afford Mannich bases in good yields when activated by means of an acidic reagent such as acetyl chloride or sulphur dioxide: the principal compound studied was Full-size image (< 1 K)