New CF2-containing building blocks, ethyl 3-ethoxy-2, 2-difluoro-3-hydroxy-propionate and- propioamide, were prepared via formylation of α, α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α, α- difluoro-functionalized esters and amides.
