New cyclobutyl analogs of adenosine and guanosine. Part 1. Synthesis of the 9??[3, 3??bis (hydroxymethyl) cyclobutyl] purine nucleoside analogs

…, M Legraverend, E Bisagni, C Huel

文献索引：Boumchita; Legraverend; Huel; Bisagni Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1815 - 1819

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被引用次数: 11

摘要

Abstract The synthesis of 1-amino-3, 3-bis (benzyloxymethyl) cyclobutane has been performed from 3, 3-bis (benzyloxymethyl) cyclobutanone, via the corresponding oxime which was reduced with lithium aluminum hydride. The amine thus obtained led to two new cyclobutyl analogs of adenosine and guanosine which were devoid of antiviral activity against HSV-1, HCMV and HIV in cell culture.