Taking advantage of a proposed hydrophobic region on 5-HTz receptors previously identified by radioligand-binding studies utilizing various phenylisopropylamine derivatives, we prepared and evaluated several N l-and/or Cl-alkyl-substituted derivatives of a- methyltryptamine in order to improve its affinity and selectivity. It was determined that substitution of an n-propyl or amyl group has similar effect on affinity regardless of location ...
