Tetrahedron Letters

Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: high-yielding synthesis of ibuprofen analogs

DB Ramachary, MS Prasad

文献索引：Ramachary, Dhevalapally B.; Shiva Prasad Tetrahedron Letters, 2010 , vol. 51, # 40 p. 5246 - 5251

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被引用次数: 10

摘要

A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with aldehydes/ketones and 1, 4- dihydropyridine via iminium-catalysis has been developed. Many TCRA reaction products have direct applications in agricultural and pharmaceutical chemistry.