Tetrahedron

On the synthesis of pyrinodemin A. Part 1: The location of the olefin

SP Romeril, V Lee, JE Baldwin, TDW Claridge

文献索引：Romeril, Stuart P.; Lee, Victor; Baldwin, Jack E.; Claridge, Timothy D.W. Tetrahedron, 2005 , vol. 61, # 5 p. 1127 - 1140

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被引用次数: 10

摘要

The elucidation of the structure of the cytotoxic marine sponge alkaloid pyrinodemin A by synthesis is described. Based on the 13C NMR spectra of three double bond positional isomers and the natural product, it is concluded the C14′–C15′ isomer best represents the true structure of pyrinodemin A. In addition, the structural assignment of pyrinodemin C is evaluated.