Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine

K Bhandari, S Srivastava, G Shankar, C Nath

文献索引：Bhandari, Kalpana; Srivastava, Shipra; Shankar, Girija; Nath, Chandishwar Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2535 - 2544

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被引用次数: 6

摘要

Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes (7–21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant activities. For SAR studies the related acyclic analogues (22–27) were also prepared. Out of the 21 synthesized compounds, 10 compounds (9, 10, 11, 15, 16, 18, 21, 22, 23 and 27) exhibited significant anorexigenic activity (at 75μmol/kg). ...