Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine

K Bhandari, S Srivastava, G Shankar, C Nath

Index: Bhandari, Kalpana; Srivastava, Shipra; Shankar, Girija; Nath, Chandishwar Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2535 - 2544

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Citation Number: 6

Abstract

Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes (7–21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant activities. For SAR studies the related acyclic analogues (22–27) were also prepared. Out of the 21 synthesized compounds, 10 compounds (9, 10, 11, 15, 16, 18, 21, 22, 23 and 27) exhibited significant anorexigenic activity (at 75μmol/kg). ...