Catalytic oxidations of steroid substrates by artificial cytochrome P-450 enzymes

…, B Gabriele, S Belvedere, Y Huang…

文献索引：Yang, Jerry; Gabriele, Bartolo; Belvedere, Sandro; Huang, Ying; Breslow, Ronald The Journal of organic chemistry, 2002 , vol. 67, # 15 p. 5057 - 5067

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被引用次数: 172

摘要

Catalysts comprising manganese-porphyrins carrying cyclodextrin binding groups are able to perform hydroxylations with substrate selectivity and regio-and stereoselectivity and high catalytic turnovers. The geometries of the catalyst/substrate complexes override intrinsic substrate reactivities, permitting attack on geometrically accessible saturated carbons of steroids in the presence of secondary carbinol groups and carbon-carbon double bonds, ...