Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs

B Klenke, M Stewart, MP Barrett, R Brun…

文献索引：Klenke; Stewart; Barrett; Brun; Gilbert Journal of Medicinal Chemistry, 2001 , vol. 44, # 21 p. 3440 - 3452

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被引用次数: 105

摘要

The P2 transporter is a nucleoside transporter which is unique to the protozoan parasite Trypanosoma brucei, the causative organism of Human African Trypanosomasis. The transporter has been shown to bind some structural motifs not recognized by other transporters. In this paper we describe the use of the melamine motif, a substrate of the P2 transporter, as a potential tool to selectively deliver polyamine analogues to the parasites. ...