A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues

…, M Ikuta, I Suzuki-Takahashi, T Hayama…

文献索引：Honma; Hayashi; Aoyama; Hashimoto; Machida; Fukasawa; Iwama; Ikeura; Ikuta; Suzuki-Takahashi; Iwasawa; Hayama; Nishimura; Morishima Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4615 - 4627

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被引用次数: 135

摘要

Identification of a selective inhibitor for a particular protein kinase without inhibition of other kinases is critical for use as a biological tool or drug. However, this is very difficult because there are hundreds of homologous kinases and their kinase domains including the ATP binding pocket have a common folding pattern. To address this issue, we applied the following structure-based approach for designing selective Cdk4 inhibitors:(1) ...