Ammonium chloride-catalyzed synthesis of benzo-fused heterocycles from o-substituted anilines and orthoesters

C Fortenberry, B Nammalwar…

文献索引：Fortenberry, Chelsea; Nammalwar, Baskar; Bunce, Richard A. Organic Preparations and Procedures International, 2013 , vol. 45, # 1 p. 57 - 65

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被引用次数: 11

摘要

Benzimidazoles, benzoxazoles and benzothiazoles have been targets in numerous synthetic studies due to their diverse biological activities as anti-viral, 1 anti-bacterial, 2 anti- fungal, 3 anti-microbial, 4 anti-Parkinson, 5 anti-cancer6 and anti-tumor7 agents, and also as drugs for the treatment of diabetes. 8 The benzimidazole scaffold is present in various anthelmintic drugs such as albendazole9 and mebendazole. 10 Similarly, benzoxazole is ...