Chemical Communications

New Pd-catalyzed selective reduction of carboxylic acids to aldehydes

LJ Gooßen, K Ghosh

文献索引：Goossen, Lukas J; Ghosh, Keya Chemical communications (Cambridge, England), 2002 , # 8 p. 836 - 837

全文：HTML全文

被引用次数: 2

摘要

A catalyst generated in situ from palladium acetate and tricyclohexylphosphine efficiently catalyzes the reduction of carboxylic acids with sodium hypophosphite in the presence of pivalic anhydride to give aldehydes with high selectivity. The low cost and convenient handling of the reagents makes this process a valuable alternative to hydrogenations and metal hydride reductions.