Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of …
SJF Macdonald, MD Dowle, LA Harrison…
文献索引：Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3878 - 3890
... Journal of Medicinal ... this risk, we rapidly explored a wide range of piperidinocrotyl side chain replacements by using the latest medicinal chemistry technologies (libraries ... Third, if we were successful in improving potency in HWB, then this could reduce the cost of the medicine. ...
