Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of …

SJF Macdonald, MD Dowle, LA Harrison…

Index: Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3878 - 3890

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Citation Number: 57

Abstract

... Journal of Medicinal ... this risk, we rapidly explored a wide range of piperidinocrotyl side chain replacements by using the latest medicinal chemistry technologies (libraries ... Third, if we were successful in improving potency in HWB, then this could reduce the cost of the medicine. ...