Derivatives of 6-Aminopenicillanic Acid. VI. Synthesis of Some Derivatives of 6-Aminothiopenicillanic Acid1

…, RR Fraser, JC Godfrey, CT Holdrege…

文献索引：Gottstein; Babel; Crast; Essery; Fraser; Godfrey; Holdrege; Minor; Neubert; Panetta; Cheney Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 794 - 797

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被引用次数: 6

摘要

Alixed alkosyforriiic atihydridea (11) of vitrioris peiiic~ illiiis (I j have Ixxii c~ iiverted iiiio the cwrresputidiiig N-arglated 6-arninothioperiirillanic. acids (111) 4 by t reairmelit with SaSII, These penicillin i hioxids have beeii oxidized to the correspoiiding amorphous bis (acg1) disrdfides (IY) by meaiis of iodine, aiid otic represeiitativcb disulfide has beeii described. In general, the penicillin t. hioacids and their wrrespoiidiiig disulfides we poteiil antimicrobial ...