Synthesis and evaluation of new 2-piperazinylbenzothiazoles with high 5-HT 1A and 5-HT 3 affinities

O Diouf, P Depreux, D Lesieur, JH Poupaert…

文献索引：Diouf; Depreux; Lesieur; Poupaert; Caignard European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 715 - 719

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被引用次数: 33

摘要

Original 2-piperazinylbenzothiazole derivatives were synthesized and studied as mixed ligands for serotoninergic 5-HT1A and 5-HT3 receptors. The studied compounds exhibited significant affinities for these two serotoninergic receptor subtypes. The pharmacological profile of these ligands was agonist for 5-HT1A receptors and antagonist for 5-HT3 receptor subsites. Compounds with such a pharmacological profile are of clinical relevance in the ...