Thyromimetics. I. The Synthesis and Hypocholesteremic Activity of Some 3'and 3', 5'-Alkyl and Aryl-3, 5-diiodothyronines

B Blank, FR Pfeiffer, CM Greenberg…

文献索引：Blank,B. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 554 - 560

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被引用次数: 31

摘要

The syntheses of a number of alkyl and aryl derivatives of 3, j-diiodotliyronine are described. lhplienyl ethcr intermediates required for these syntheses were prepared by one of two general procedures. The ability of the final compounds (I17a-h and XIa, d) to lower plasma cholesterol levels in rats fed a cholesterol-cholic acid diet is also reported.