Compounds from Danshen. Part 4. structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge ( …
HM Chang, KY Chui, FWL Tan, Y Yang…
文献索引：Chang; Chui; Tan; Yang; Zhong; Lee; Sham; Wong Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1675 - 1692
Twenty one o-quinonoid-type compounds and one coumarin-type compound related to miltirone (1) have been synthesized with the aim to identify the key structural elements involved in miltirone's interaction with the central benzodiazepine receptor. On the basis of their inhibition of [SH] flunitrazepam binding to bovine cerebral cortex membranes, it is apparent that ring A of miltirone is essential for affinity. Although increasing the size of ring ...
